MAPT and early-onset autosomal dominant Alzheimer disease: In addition to the previously documented positive effects of a TREM2-related microglial response in advanced Alzheimer's disease, my study demonstrates that in individuals with initial Aβ abnormalities, TREM2-related microglial activation associated is linked to reduced regional accumulation of tau aggregates and also, spreading across inter-connected brain regions, as evaluated through fMRI connectomes during the early Alzheimer's disease pathological events.