This indicates that microglial activation could be associated with tau hyperphosphorylation and potentially play a role in the development of tau pathology in Alzheimer's disease.26 Conversely, a higher TREM2-related microglial response has been associated with reduced cognitive decline, amyloid accumulation and neurodegeneration in individuals with symptomatic sporadic and autosomal dominant Alzheimer's disease.27,28. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.