TREM2 and Alzheimer disease: This indicates that microglial activation could be associated with tau hyperphosphorylation and potentially play a role in the development of tau pathology in Alzheimer's disease.26 Conversely, a higher TREM2-related microglial response has been associated with reduced cognitive decline, amyloid accumulation and neurodegeneration in individuals with symptomatic sporadic and autosomal dominant Alzheimer's disease.27,28