Can significantly attenuate atherosclerosis development in SR-B1 KO/ApoER61h/h mice (Rivera et al., 2019), Inhibit LDL oxidation and thereby can prevent the onset of atherosclerosis development (Pérez-Jiménez and Saura-Calixto, 2008); in vivo studies showed cardioprotective effects by measuring creatine kinase levels and by ECG monitoring (Pop et al., 2018). The gene discussed is SCARB1; the disease is atherosclerosis.