ALDH2 deficiency enlarged myocardial infarct size, increased CK-MB, LDH and 4-HNE; iron accumulation; MDA production; glutathione depletion; GPX4 inactivation; increased ACSL4 and TfR1; downregulated FTH1and GPX4. Here, ALDH2 is linked to myocardial infarction.