A study by Prudente et al. (2022), subsequent to that of Philippi et al. (2021), investigated the role of ONECUT1 variants in Italian patients with various forms of nonautoimmune diabetes mellitus, including permanent neonatal diabetes mellitus (PNDM), familial diabetes, and early- and late-onset T2D. This evidence concerns the gene ONECUT1 and type 2 diabetes mellitus.