The findings of Philippi et al. (2021), Prudente et al. (2022), Russ-Silsby et al. (2023), and our study suggest that ONECUT1 is potentially associated with clinical diversity in diabetes, such as neonatal syndromic diabetes, insulin-requiring diabetes, insulin-requiring diabetes, MODY, T1D, and early- and late-onset T2D. This evidence concerns the gene ONECUT1 and diabetes mellitus.