A more recent report by Russ-Silsby et al. (2023), identified a homozygous frameshift variant in ONECUT1 as the cause of neonatal diabetes in one individual referred from India to Exeter Monogenic Diabetes Cohort; they further found, by way using a rare variant burden test in the UK Biobank European cohort, a significant association between heterozygous ONECUT1 null variants and type 2 diabetes. Here, ONECUT1 is linked to type 2 diabetes mellitus.