EGFR and neoplasm: Zhou et al found that combining CAR-T cells targeting EGFR with radiation therapy effectively enhanced the immune function and anti-tumor efficacy in immunodeficient in situ TNBC mice.147 Effective chemotherapy reduction improved the short-term ORR and long-term OS of CAR-T-cell therapy in R/R DLBCL patients with high-tumor loads, resulting in outcomes comparable with those of patients with low tumor loads.148