PSMA2 and Miyoshi myopathy: For KYDAR clinical trial patients or primary refractory MM (PRMM) patients, this study established a unique MM resistance pattern including stimulation of proteasome machinery (PSMB4 and PSMA2), mitochondrial stress (COX6C, COX7A2), ER and UPR pathway (PPIA, STMN1), as well as downregulation of PC checkpoint genes.