The expression of CD38 in adaptive NK cells was lower than that in conventional NK cells, thus avoiding CD38 monoclonal antibody daratumumab-induced fratricide and increasing daratumumab efficacy by mediating ADCC to kill tumor cells.140 Li et al further divided NK cells into 7 subsets through unsupervised clustering, among which ZNF683+ NK subset was significantly increased in MM compared with healthy donors. This evidence concerns the gene CD38 and neoplasm.