There were no significant difference in terms of age, BMI, hypertension, diabetes, history of pelvic surgery, PSA before biopsy, ISUP grade before biopsy and after LRP, prostate volume, the interval between biopsy and RP, metastasis, and PNI between non-PSM and PSM groups (all p>0.05). This evidence concerns the gene KLK3 and hypertensive disorder.