There were no significant difference in terms of age, BMI, hypertension, diabetes, history of pelvic surgery, PSA before biopsy, ISUP grade before biopsy and after LRP, prostate volume, the interval between biopsy and RP, metastasis, and PNI between non-PSM and PSM groups (all p>0.05). The gene discussed is KLK3; the disease is diabetes mellitus.