MASP2 and gestational diabetes: High LPC18:0 also played a significant mediating role in the association between low DCA and GDM (P for Sobel test <0.001) but not in the association between high MASP-2 and GDM because the adjustment for LPC18:0 increased the OR of high vs. low MASP-2 for GDM from 3.12 to 3.48 (Tables 2, 4).