If by one side, adrenal steroids may modify the immune cells functioning and therefore alter the progression of autoimmune diseases; on the other, pro-inflammatory cytokines such as IL (interleukin)-1B, TNF (tumoral necrosis factor)-α, and IL-6 stimulate the secretion of the corticotrophin-releasing hormone by the hypothalamus, promoting the secretion of adrenal cortex hormones such as cortisol and DHEA.1–3. The gene discussed is TNF; the disease is autoimmune disease.