FMF is the most common hereditary autoinflammatory disease, affecting Arabs, Turks, Armenians, and non-Ashkenazi Jews from the East Mediterranean region and surrounding areas.17–18 Although this disease affects Arab societies, there is no sufficient data regarding the prevalence of FMF in Arab countries, including Palestine, where the study was done.19 In this study, we aim to identify the most frequent MEFV mutations as well as to evaluate the clinical profile and response to colchicine treatment in patients with genetic variance. The gene discussed is MEFV; the disease is familial Mediterranean fever.