These results were confirmed by another study.7 Furthermore, similar findings were reported by Bournia et al. who investigated four subgroups: ACA(+) SS, ACA(−) SS, ACA(+) SSc/sicca(+), and ACA(+) SSc/sicca(−).11 The finding of ACA in SS was consistent with a lower prevalence of anti-Ro/SSA and anti-La/SSB antibodies than its ACA(−) counterparts and milder CREST (Calcinosis, RP, Esophageal Dysmotility, Sclerodactyly, Telangiectasias) phenotype compared to lcSSc. The gene discussed is CALR; the disease is systemic sclerosis.