TRPC6 and cardiac hypertrophy: sKLA promotes the function of most transporters and channel proteins; however, there are exceptions, such as the presence of transient receptor potential cation channel 6 (TRPC6), long-term high pressure, abnormal calcium signal, activated calcineurin and the nuclear factor of activated T cell, upregulated expression of the TRPC6 gene, and increased TRPC channel protein on the cell surface, which lead to increased calcium influx and long-term enhancement of myocardial contractility, eventually causing cardiac hypertrophy [26,75].