With SPOP overexpressing, 25 DisGeNET with padj <0.05 were identified, including neoplasm invasiveness, undifferentiated carcinoma, hepatic methionine adenosyltransferase deficiency, steatohepatitis, and so on (Figure 3d, Table S5). Here, SPOP is linked to hyperinsulinemic hypoglycemia, familial, 4.