Table 2 shows the crude and multivariable Cox regression analyses for baseline renin levels for all-cause mortality and unplanned HF hospitalization. Subgroup analysis is provided in Supplementary Figure 1. Baseline renin levels were not associated with all-cause mortality (crude HR for an increase of 100 μiE/ml 1.01 (95% CI: 0.99–1.02), p = 0.414). This was congruent with comparable survival curves for different renin tertiles (p = 0.5503, log-rank test) and for normal vs. elevated renin levels (p = 0.3790, log-rank test) in the Kaplan-Meier analysis (Figure 3(a)). Here, REN is linked to hydrops fetalis.