TARDBP and amyotrophic lateral sclerosis: This is particularly important for understanding the pathogenesis of ALS since assessment of pTDP-43 pathology in sporadic and familial ALS patients indicates that mislocalization of TDP-43 occurs in discrete stages (post-developmentally) as the disease progresses (Braak et al., 2013; Brettschneider et al., 2013).