On the other hand, the expression of general neuroendocrine markers, such as chromogranin A, synaptophysin, and neuron-specific enolase, and the ECL cell marker histidine decarboxylase (HDC) has been shown repeatedly by immunohistochemistry in gastric carcinomas, especially in tumors of the diffuse type (10, 11). Here, HDC is linked to gastric carcinoma.