Interferons are glycoproteins with antiviral, anti-proliferative, anti-tumor, and immunoregulatory actions, including IFN-γ from the type II IFN family, which has been considered an antitumor candidate because of the function of inhibiting proliferation, inducing apoptosis, and suppressing tumor-derived cytokines by complex mechanisms (32–34). This evidence concerns the gene IFNG and neoplasm.