Gillies et al. demonstrated that oral bicarbonate could boost the immunotherapeutic efficacy of anti‐PD1, anti‐CTLA‐4, or adoptive T‐cell transfer.[170] To reduce the risk of alkalosis and improve the efficiency of pH regulation, some “alkaline” nanoparticles have been utilized for remodeling immunosuppressive TME to improve the response rate to immunotherapy.[154, 171] For instance, Gu's group developed a CaCO3‐contained sprayed immunotherapeutic gel to inhibit postoperative tumor recurrence. Here, CTLA4 is linked to neoplasm.