In summary, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were statistically significantly associated with poor prognosis among patients with stage I EGFR-altered lung adenocarcinoma after surgery, and the established nomogram with the neutrophil to lymphocyte and platelet to lymphocyte ratios could predict patient prognosis more accurately than the nomogram without these ratios. Here, EGFR is linked to lung adenocarcinoma.