Caveolin-1 (Cav-1), a structural and signaling protein on the cytoplasmic membrane, plays vital roles in various liver diseases [16, 17], including a spectrum of conditions such as alcoholic fatty liver disease, NAFLD, fibrosis, liver cirrhosis, and hepatocellular carcinoma [18]. The gene discussed is CAV1; the disease is metabolic dysfunction-associated steatotic liver disease.