Indeed, we observed in the in vivo co-injection experiments that NSCLC NCI-H292 cells implanted with gMSI2 CAFs, but not with Ctrl CAFs, expressed a high level of the epithelial marker E-cadherin and a low level of the mesenchymal marker vimentin in the primary NSCLC tumor tissues, as evaluated by IHC (Fig. 6A), indicating an impaired EMT in the gMSI2 CAF group. Here, CDH1 is linked to neoplasm.