Given that IL-6 was the most significantly downregulated cytokine in gMSI2 CAF-CM (Fig. 4B), and that it is known to be associated with poor survival in NSCLC patients [35] and increased cell motility [36], we further investigated whether IL-6 is a key mediator of CAF-induced NSCLC cell invasion. The gene discussed is IL6; the disease is non-small cell lung carcinoma.