TNFRSF11B and non-small cell lung carcinoma: As shown in Fig. 4B, depletion of MSI2 in CAFs affected their secretome—lower secretion of several soluble factors known to be associated with metastasis and poor prognosis in NSCLC patients, such as osteoprotegerin [32], MIP-3α [33], and IL-1β [34], was detected.