As depletion of MSI2 in human NSCLC cell lines reduced its invasion and metastatic potential [17], we suggest that MSI2 small molecule drugs in NSCLC may have a dual effect, i.e., not only by targeting and weakening tumor cells but also inactivating CAFs in the TME, thereby enhancing their effectiveness in NSCLC treatment. Here, MSI2 is linked to non-small cell lung carcinoma.