Blocking of IL-6 with IL-6 Ab in the Ctrl CAF-CM completely reversed the promoting effect of Ctrl CAF-CM on NSCLC cell motility (Fig. 5A; Ctrl CAF-CM+/−IgG or IL-6 Ab) to a similar degree as that observed in NSCLC cells treated with gMSI2 CAF-CM. This evidence concerns the gene IL6 and non-small cell lung carcinoma.