Addition of IL-6 to the CM from MSI2-depleted CAFs restored the EMT in NSCLC cells, in parallel with an observed rescue in NSCLC spreading impairment in 2D and 3D invasion assays, thus supporting secreted IL-6 as a key mediator of the tumor-promoting effects of CAFs mediated by MSI2 via EMT. Here, MSI2 is linked to neoplasm.