IL6 and non-small cell lung carcinoma: Quantitative analysis of the invasive distance from NSCLC spheroids of different groups is shown in Fig. 5C. Importantly, the occurrence of disseminated events was significantly reduced in NSCLC spheroids exposed to Ctrl CAF-CM in the presence of IL-6 Ab (Fig. 5D; Ctrl CAF-CM+/−IgG or IL-6 Ab), and by contrast the reduced disseminated events in NSCLC spheroids exposing to gMSI2 CAF-CM were rescued by the presence of IL-6 (Fig. 5D; gMSI2 CAF-CM+/−IL-6).