Similarly, we observed, that 14q deletions were heterogenous in size, they covered centromeric or telomeric regions of IGH and, in some cases, TRAF3. It might be interesting to investigate this lesion in other CLL-RT populations, considering, that IGH deletions were the only alterations in our RT patients, which have never been acquired at transformation, but maintained from CLL/SLL phase. This evidence concerns the gene TRAF3 and B-cell chronic lymphocytic leukemia.