In a recent study performed in a model of tauopathy characterized by the accumulation of tau aggregates induced by the expression of a mutant tau carrying frontotemporal dementia (FTD)-linked mutation P301S [47], single-nuclei RNA sequencing of hippocampi suggested that Cgas and Sting (Tmem137) are predominantly expressed in microglia. The gene discussed is MAPT; the disease is tauopathy.