Yu et al. [29] detected cGAS-STING activation in motor neurons derived from induced pluripotent stem cells (iPSCs) from patients with mutations in TARDBP (encoding TDP-43) and a mouse model of ALS with human mutant TDP-43 overexpression (Prp-TDP-43A315T). Here, STING1 is linked to amyotrophic lateral sclerosis.