COMT and Tremor: Other drug options include Amantadine to help with tremors, Catechol-O-methyl transferase (COMT) inhibitors to prevent COMT from deactivating levodopa, Anticholinergic drugs to reduce tremors by blocking the neurotransmitter acetylcholine, and Adenosine A2A receptor antagonists, which can work in a similar manner to levodopa to reduce symptoms during levodopa ‘off times’.