In brief, we integrated miRNA-mRNA regulatory network in TM and AH of POAG, and identified 2 miRNAs (miR-106b-5p, miR-15a-5p) as potential biomarkers, and 3 genes (CREB1, CAPZA2, SLC2A3) as driving factors for POAG. The gene discussed is CREB1; the disease is open-angle glaucoma.