Moreover, the upregulation of VEGFR, phosphorylated and total Smad2/3 mediated by CRC cell-derived exosomes were abolished by sh-circCOL1A1, whereas EIF4A3 overexpression reversed these negative effects on VEGFR and Smad2/3 expression (Fig. 6A). Here, SMAD2 is linked to colorectal carcinoma.