Interestingly, comparing tumor and normal adjacent ccRCC tissue samples, Li et al. report EIF4EBP1, another member of the translation initiation complex, as a downstream substrate of mTOR, and EIF4EBP1 phosphorylation was decreased in vitro by mTOR inhibition [58]. This evidence concerns the gene EIF4EBP1 and nonpapillary renal cell carcinoma.