However, western blot analysis demonstrated that protein levels of PGC1α (a master regulator of mitochondrial biogenesis), NDUFAF1 (a protein involved in complex I assembly), ATP5A1 (a mitochondrial ATP synthase), and TFAM (the most abundant protein associated with mitochondrial DNA) were comparable among cardiac samples from WT and the three EDMD mouse models (Additional file 1: Fig. S1). Here, PPARGC1A is linked to Emery-Dreifuss muscular dystrophy.