EMD and Emery-Dreifuss muscular dystrophy: In mouse models of EDMD, emerin-deficient Emd−/− (Emd) mice do not show obvious dystrophic or cardiomyopathic phenotypes [8], and LmnaH222P/H222P (H222P) knock-in mice recapitulate the cardiac phenotypes of EDMD patients, but only demonstrate limited phenotypes in skeletal muscle after the appearance of cardiac dysfunction [9].