Compared with WT mice, phosphorylated mTOR was significantly increased in H222P mice at 18 weeks but not at 30 weeks of age, and total mTOR level was significantly increased in EH mice at 30 weeks, whereas phosphorylated AKT and total AKT levels were comparable among the EDMD mice of different ages. The gene discussed is MTOR; the disease is Emery-Dreifuss muscular dystrophy.