Meanwhile, TF activity (tumor-derived and mice-derived) in the plasma of mice bearing H2228 is highest (H2228 vs. H1299, P = 0.021; H2228 vs. blank control, P = 0.006), followed by H1299 and blank control (H1299 vs. blank control, P < 0.001) (Fig. 2.F). This evidence concerns the gene TF and neoplasm.