The present study compared prophylactic treatment-naïve patients with episodic and CM to age/sex matched controls and found that patients with migraine, especially CM, had a pro-inflammatory state (higher hsCRP levels), an altered endothelial profile with lower levels of vasodilator factors (nitrate, nitrite, and isoprostanes), and worse vascular and pro-coagulant profiles (HDL cholesterol, vWF antigen and activity, and CIMT) compared with controls. The gene discussed is VWF; the disease is cutaneous mastocytosis.