Moreover, while changes from T0 was observed in treatment responders in all endothelial dysfunction biomarkers investigated (Table 3), only theses inflammatory and endothelial dysfunction biomarkers were significantly changed: hsCRP levels decreased from 2.54 to 1.69 mg/dL (p = 0.045), vWF activity levels decrease from 124 to 103 IU/dL (p = 0.003), HDL cholesterol levels decreased from 61.7 to 55.5 mg/dL (p = 0.030) and prothrombin activity decreased from 1.01 to 0.93 (p = 0.01). Here, VWF is linked to endothelial dysfunction.