CD8A and COVID-19: Our analyses showed that there were distinct organisations amongst immune cells in COVID-19 lungs, with specific predilection of immature neutrophil for CD8 T cells, and upon connection (as the neutrophil_CD8_ADJ cluster), a further connection with Mono_CD31_ADJ cluster was formed, resulting in a network of Neut_CD8_ADJ and Mono_CD31_ADJ, linked to proliferating alveolar epithelium in diffuse alveolar damage.