ANXA5 and osteoporosis: We found that compared with the sham mice, osteoporotic mice showed a lower bone mass (BMD and BV/TV) and poorly organized trabecular architecture (Tb.N, Tb.Th, and Tb.Sp), which is consistent with the known pathological characteristics of osteoporosis.1,41 After injection with AnxA5, the osteoporotic bone loss in ovariectomized mice was strikingly relieved.