It remains mysterious whether Lis1’s roles in these two regulatory pathways are coupled together, but the removal of the α subunit of PAF-AH1B did not result in defects in neurodevelopment61, suggesting that the Lissencephaly phenotype is distinct from Lis1’s role in the PAF-AH1B pathway. This evidence concerns the gene PAFAH1B1 and lissencephaly spectrum disorders.