PCSK9 and myocardial ischemia: For PCSK9, the cis-pQTL from UKB (rs11591147; MAF [minor allele frequency] = 0.01), but not from CKB (rs572512; MAF = 0.73), was strongly and positively associated with IHD (aHR: 1.25 [95% CI: 1.20-1.30] vs aHR: 0.94 [95% CI: 0.90-0.98]) (Figure 4).