In a previous report from the DECODE study of 35,559 individuals, 1,287 of 4,907 proteins measured using SomaScan platform were significantly associated with myocardial infarction (MI) (n = 3,457 cases), with the top 3 proteins being NPPB (HR: 1.64 per 1-SD higher concentration), MMP-12 (1.55), and CTHRC1 (1.50).9 This evidence concerns the gene NPPB and myocardial infarction.