In Model 2, 558 proteins were significantly associated at FDR <0.05 with risk of IHD (548 positively, 10 inversely) (Supplemental Table 3), with the top 5 positive protein associations being NT-proBNP (adjusted HR: 1.88; 95% CI: 1.67-2.11 per 1-SD higher concentration), WFDC2 (adjusted HR: 1.66; 95% CI: 1.46-1.88), pro-adrenomedullin (adjusted HR: 1.63; 95% CI: 1.41-1.89), EDA2R (adjusted HR: 1.62; 95% CI: 1.36-1.92), and GFRA1 (adjusted HR: 1.61; 95% CI: 1.42-1.82). This evidence concerns the gene NPPB and myocardial ischemia.