Elevated Aβ and tau measured by either PET or CSF (Quigley et al., 2011; Stephan et al., 2012), brain atrophy (Pini et al., 2016), and functional network dysfunction (Ibrahim et al., 2021; Puttaert et al., 2020) are associated with cognitive status along the AD continuum. Here, MAPT is linked to Alzheimer disease.