The observations that DTX3L/PARP9 assemblesinto an oligomer in vitro14 and that thenative complex from prostate cancer cells has an apparent size >500kDa15 both indicated that the complex thatbinds ADP-ribosylated AR contains multiple MDs; theoretically, thesecould engage multiple ADP-ribosyl Cys sites in AR. The gene discussed is AR; the disease is Familial prostate cancer.