HMGCR and exocrine pancreatic carcinoma: For instance, when overexpressed in pancreatic carcinoma (PC), lncRNA ZFAS1 can stabilize and increase HMGCR mRNA to promote lipid accumulation in PC by binding to U2AF2, one component of spliceosomes.[126] Moreover, a bioinformatic analysis of the roles of lncRNA in facilitating epigallocatechin‐3‐gallate (EGCG) on cholesterol metabolism identified lncRNA AT102202 with potential to target HMGCR mRNA for regulating cholesterol metabolism of HepG2 cells.