ACSL4 and cancer: The ACSLs isoforms mainly involves both anabolic (lipogenesis) and catabolic pathways (fatty acid oxidation and lipolysis), among which ACSL1 and ACSL4 are the most extensively studied in the lipid metabolic reprogramming of cancer.[146, 147] The lipid‐metabolic related lncRNAs and circRNAs in cancers have also been discovered to play roles in the regulation of ACSL1 and ACSL4 expressions (Figure 5 and Table 3).