VEGF expression in cancer is usually mediated by multiple regulators, such as loss of p53 and VHL function or activation of Ras oncogene.[188, 189] Recent evidence demonstrates that lipid‐metabolic‐related lncRNAs and circRNAs in cancer can also regulate tube formation of HUVECs in cancer tissues via lipid metabolism reprogramming. The gene discussed is VEGFA; the disease is cancer.