VEGF expression in cancer is usually mediated by multiple regulators, such as loss of p53 and VHL function or activation of Ras oncogene.[188, 189] Recent evidence demonstrates that lipid‐metabolic‐related lncRNAs and circRNAs in cancer can also regulate tube formation of HUVECs in cancer tissues via lipid metabolism reprogramming. This evidence concerns the gene TP53 and cancer.