MACC1‐AS1 then promoted the FAO‐dependent stemness property and chemotherapy resistance of GC.[143] Furthermore, lncRNA AGAP2‐AS1 was overexpressed to promote stemness and trastuzumab resistance in breast cancer co‐cultured with MSCs via CPT1‐mediated FAO.[141] Cholesterol biosynthesis has been shown to be of importance in maintaining the stemness property and chemotherapy resistance of cancer stem cells (CSCs). The gene discussed is CPT2; the disease is gastric cancer.