SREBP proteins come into three isoforms, with SREBP‐1a and SPREBP‐1c primarily governing fatty acids and TG's biosynthesis, while SREBP‐2 selectively facilitates the expression of enzymes involved in cholesterol biosynthesis.[73, 74] These processes are highly regulated by intracellular levels of sterols, status of PI3K/Akt /mTOR signaling, and extracellular insulin and growth factors.[5] which are always dysregulated in various cancers, including glioblastomas, breast cancer and HCC.[75, 76, 77, 78, 79]. The gene discussed is AKT1; the disease is breast carcinoma.