For instance, when overexpressed in pancreatic carcinoma (PC), lncRNA ZFAS1 can stabilize and increase HMGCR mRNA to promote lipid accumulation in PC by binding to U2AF2, one component of spliceosomes.[126] Moreover, a bioinformatic analysis of the roles of lncRNA in facilitating epigallocatechin‐3‐gallate (EGCG) on cholesterol metabolism identified lncRNA AT102202 with potential to target HMGCR mRNA for regulating cholesterol metabolism of HepG2 cells. This evidence concerns the gene HMGCR and pachyonychia congenita.