SREBF1 and cancer: Additionally, some lipid‐metabolic related lncRNAs and circRNAs in cancer can modulate LDLR expression epigenetically.[131] For example, as an antisense RNA that overlaps the promoter of the LDLR gene, lncRNA BM450697 can decrease the expression of LDLR by inhibiting interaction between RNA polymerase II (Pol II) or transcription factor SREBP1a and the promoter of LDLR in HCC.[132]