MACC1‐AS1 then promoted the FAO‐dependent stemness property and chemotherapy resistance of GC.[143] Furthermore, lncRNA AGAP2‐AS1 was overexpressed to promote stemness and trastuzumab resistance in breast cancer co‐cultured with MSCs via CPT1‐mediated FAO.[141] Cholesterol biosynthesis has been shown to be of importance in maintaining the stemness property and chemotherapy resistance of cancer stem cells (CSCs). This evidence concerns the gene MACC1 and gastric cancer.