PNPLA2 and cancer: Thereinto, ATGL is a rate‐limiting enzyme but its roles are complex in different types of cancer.[69, 70] For instance, ATGL can promote proliferation and invasiveness in prostate, lung and colorectal cancer cells, but acts as a suppressor of malignancy in other types of cancers.[70, 71] More interestingly, breast cancer cells can obtain free fatty acids to promote autologous proliferation and migration via ATGL‐dependent lipolysis in both itself and adipocytes in the local environment.[72]