AKT1 and breast carcinoma: This process then leads to the activation of the PI3K/Akt signaling and ultimately regulates the stemness of breast cancer stem cells (BCSC).[128] Phospholipid metabolism‐related lncROPM has been recently identified to promote PLA2G16‐mediated phospholipid lipolysis and the release of free fatty acid, which activates the PI3K/AKT, Wnt/β‐catenin, and Hippo/YAP signaling pathways, thereby involving in the maintenance of breast CSCs stemness.[196]