AKT1 and cancer: In addition to these nuclear transcription factors, some oncogenic signaling pathways take part in regulating lipid metabolism to shape the tumors’ unique lipidome.[45] The PI3K‐AKT‐mTOR pathway, which is regularly disrupted in a variety of human cancers, can be induced by activating growth‐factor receptor tyrosine kinases (RTKs), as shown in Figure 2.