Furthermore, in our paper we demonstrated that the Combo‐NP enchanced the therapeutic efficacy of anti‐programmed death‐ligand 1 (PD‐L1) antibody through increasing the expression of PD‐L1 and converting the “cold tumor” into “hot tumor”, the combination of anti‐PD‐L1 antibody with Combo‐NP could activate the systemic immune response, demonstrating a promising inhibitory effect on tumor metastasis and abscopal immune response. The gene discussed is CD274; the disease is neoplasm.