TP53 and ulcerative colitis: Notably, downregulation of themiR-200 family and hyperactivation of the p53 pathway are verifiedin colonic tissues from patients with active ulcerative colitis (UC).Most importantly, the transient supply of miR-200 through the oraldelivery of lipid nanoparticles (LNPs) carrying miR-200 restores ISCsand promotes intestinal regeneration in mice following acute injury.Our study implies the miR-200/p53 pathway as a promising therapeutictarget for active UC patients with diminished levels of the miR-200family.