A study of peripheral blood mononuclear cells in individuals living in a region of low malaria transmission found that NK cells during a malaria episode upregulated effectors of cytotoxicity (GNLY, FCGR3A, GZMB) but also markers of suppression, such as co-inhibitory receptors HAVCR2 (Tim-3), LAG3 (CD223), and several TNFRSF members [10]. This evidence concerns the gene LAG3 and malaria.