GSDMD and Sepsis: Comparative analysis revealed sepsis upregulation of BAK1, CASP1, CASP3, CASP4, CASP5, CHMP2A, CHMP2B, CHMP6, ELANE, GSDMD, IL18, AIM2, CASP9, NLRC4, NLRP3, NLRP6, NOD2, PRKACA, TIRAP, while downregulation of CHMP4A, CHMP7, CYCS, IRF1, IRF2, TP53, CASP6, CASP8, GPX4, GSDMB, NLRP1, NOD1, PLCG1, and GZMA was observed in patients with sepsis compared to the healthy control group (Fig 1B).