STUB1 and heart failure: In subset analyses, CHIP was significantly associated with increased risk of heart failure (HR, 4.02; 95% CI, 2.32-6.98), CAD (HR, 2.22; 95% CI, 1.06-4.63), and stroke (HR, 3.02; 95% CI, 1.07-8.52) (Figure 2; eTable 7 in Supplement 1).