IFNA2 and autoimmune polyendocrine syndrome type 1: We detected high titres (arbitrary units > 50) of anti-IFNα-2 IgG in 33 out of 56 (59%) patients with p52LOF/IκBδGOF variants, 41 out of 45 (91%) patients with APS-1, but none in those carrying p52LOF/IκBδLOF (n = 4) or p52GOF/IκBδLOF (n = 6) alleles, or with idiopathic PAD (n = 6) (Fig. 3a).