IFNA2 and autoimmune polyendocrine syndrome type 1: For comparison, 41 (91%), 43 (96%) and 1 (2%) out of the 45 patients with APS-1 neutralized IFNα, IFNω and IFNβ, respectively, at a concentration of 10 ng ml−1 (Fig. 3e and Extended Data Fig. 7a, b), and serum from all of these patients neutralized IFNα-2 and IFNω at a concentration of 100 pg ml−1 (Fig. 3c,d and Extended Data Fig. 7e).