By contrast, no AAN-I-IFNs were detected in patients with autosomal-recessive BAFFR or X-linked CD40L deficiency, or in the plasma from heterozygous relatives of patients with autosomal-recessive RELB deficiency (n = 8) (Fig. 3f–h and Extended Data Fig. 7h–j). Here, RELB is linked to hyperinsulinemic hypoglycemia, familial, 4.