CD4 and Autoimmunity: The 24 T cell clusters spanned innate-like states and CD4+ and CD8+ adaptive lineages, including states implicated in autoimmunity, such as regulatory CD4+ T cells (Treg) (T-8 and T-9) and CXCL13- and IL21-expressing T follicular helper (TFH) and TPH cells17,19 (T-3 and T-7) (Fig. 2a and Extended Data Figs. 2 and 3).