We then inferred the ability of a tumour to evade the immune response through the downregulation of target genes by examining the binding of neuroblastoma CRC transcription factors (MYCN, ASCL1, HAND2, ISL1, PHOX2B, GATA3 and TBX2; Extended Data Fig. 4a) to the parent gene locus of the prioritized antigens4. This evidence concerns the gene MYCN and neoplasm.