Specifically, CTNNA3 (cell-cell adhesion, ranked 47th), HSPA1A (heat shock protein, ranked 22nd) and PSORS1C1 (confers susceptibility to psoriasis and systemic sclerosis, ranked 88th) in our top 100 DE gene list were also associated with MDD as described in a genome-wide meta-analysis involving 807,553 individuals [65]. This evidence concerns the gene PSORS1C1 and systemic sclerosis.