DDIT4 and cancer: In accordance with this concept, an increase in the expression of DDIT4 at both the mRNA and protein levels has been observed in several types of cancer, such as colorectal carcinoma (CRC)31,32, bladder urothelial carcinoma (BUC)22, oral squamous cell carcinoma (OSCC)33, ovarian cancer (OC)28,34, and gastric cancer (GC)27.