In individuals suffering from migraine, pro-inflammatory cytokines such as Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), and Tumor necrosis factor alpha (TNF-α), along with anti-inflammatory cytokines like Interleukin 10 (IL-10), are postulated to exert an influential role in the pathogenesis of migraine10. Here, TNF is linked to migraine disorder.