This revealed an overall increased deposition by AFs of collagen family members (COLs, including COL4A1 and COL11A1), fibrillins (FBN1 and 2) and tenascin (TNC) (Fig. 4B), previously involved in lung fibrosis [37, 38] and deposited by CAFs in other cancers [39, 40]. The gene discussed is COL11A1; the disease is pulmonary fibrosis.