PDGFRA and neoplasm: Finally, using the mesothelioma transcriptional data available through The Cancer Genome Atlas (TCGA) in conjunction with the cellular deconvolution algorithm Kassandra [50] revealed that expression of SRC, PDGFRA and PDGFRB (Fig. 5F) significantly correlated with the proportion of fibroblasts within the tumour microenvironment, further suggesting the relevance of these signalling changes to the productive phenotype of this disease.