This revealed an overall increased deposition by AFs of collagen family members (COLs, including COL4A1 and COL11A1), fibrillins (FBN1 and 2) and tenascin (TNC) (Fig. 4B), previously involved in lung fibrosis [37, 38] and deposited by CAFs in other cancers [39, 40]. This evidence concerns the gene TNC and cancer.