In addition, our group has shown a possible involvement of the Nr4a gene family in the persistence of PTSD symptoms and signs [25], verifying a significant downregulation of the Nr4a1 gene expression in the hippocampus of WT mice administrated with sotalol, a peripheral β-adrenoceptor antagonist, when compared to vehicle-treated mice [54]. Here, NR4A1 is linked to post-traumatic stress disorder.